Open Hand

Overview

The Open Hand project offers a unique approach to the regulatory review process in which IVD manufacturers engage with an interactive review session and share learnings between sponsors to advance the understanding of fit-for-purpose RWD to generate RWE.

New Release

The Open Hand Initiative: Facilitating the Use of RWE

The Open Hand Initiative, led by MDIC in collaboration with the FDA and industry partners, showcases a groundbreaking approach to using real-world data (RWD) and real-world evidence (RWE) in regulatory submissions. Piloted during the COVID-19 pandemic, this initiative brought together stakeholders to openly share insights and address challenges in transitioning SARS-CoV-2 diagnostics from Emergency Use Authorization (EUA) to full FDA approval.

By fostering transparency and collaboration, the Open Hand Initiative highlights best practices for leveraging high-quality RWD to generate RWE and streamline regulatory decision-making. Discover how this innovative model is shaping the future of medical device approvals and advancing patient care.

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Open Hand Working Group

Active Open Hand Working Group members represent the following IVD stakeholders:

  • Becton Dickinson
  • Roche
  • Siemens-Healthineers

Explore ClinDx Resources

The Open Hand Initiative: Advancing Real-World Evidence in Medical Device Approvals

Study Design Blueprint for Evaluating Analytical Performance Characteristics of Point of Care In Vitro Diagnostic Devices with Capillary Whole Blood (Fingerstick) Specimens

Predetermined Change Control Plans for AI and ML-enabled Medical Devices